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Liquid dosing

Children's Liquid Benadryl Dosage for Dogs

Children's liquid diphenhydramine is the easiest way to dose small dogs accurately. Most products contain 12.5 mg in every 5 mL, so 1 mL holds 2.5 mg.

What do you have at home?

Only use plain diphenhydramine. Never give "Benadryl-D", cold-and-flu or "plus" versions, and check liquids for xylitol, which is poisonous to dogs.

Usual vet dose

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Safe range (2 to 4 mg/kg)
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How often
Every 8 to 12 h

Talk to your vet first. This calculator uses the standard veterinary dose for diphenhydramine (2 to 4 mg per kg every 8 to 12 hours, Merck Veterinary Manual). It cannot know your dog's health history. Dogs with glaucoma, heart disease, high blood pressure, seizures, prostate or thyroid problems, pregnant dogs and dogs on other medicines may need a different plan. If your dog has face swelling, hives with breathing trouble, or collapses, go to an emergency vet now. Do not wait for Benadryl to work.

Liquid Benadryl dosage chart for dogs (mL)

Dog weightmg (usual)mL of 12.5 mg/5 mL liquid
3 lb3 mg1.2 mL
5 lb5 mg2 mL
8 lb8 mg3.2 mL
10 lb10 mg4 mL
12 lb12 mg4.8 mL
15 lb15 mg6 mL
20 lb20 mg8 mL
25 lb24.9 mg10 mL
30 lb29.9 mg12 mL
40 lb39.9 mg16 mL

For dogs over 40 lb, tablets are cheaper and simpler. See the full dosage chart.

Check the label before you pour

  1. Strength: make sure it says 12.5 mg per 5 mL. Some "infant" products are more concentrated, and the chart above would then be wrong.
  2. Active ingredients: diphenhydramine only. No phenylephrine, pseudoephedrine or acetaminophen.
  3. Inactive ingredients: no xylitol (also called birch sugar). Sorbitol and sucrose are fine.

How to give liquid to a dog

Draw up the dose in a 5 or 10 mL oral syringe. Slip the tip into the pouch of your dog's cheek, behind the canine tooth, and squeeze slowly so your dog can swallow. Follow with a treat. Many children's liquids are flavored, so most dogs take them happily.

Frequently asked questions

How many mL of children’s Benadryl can I give my dog?

About 0.4 mL per pound of body weight at the usual dose (1 mg per pound with a 2.5 mg/mL liquid). A 10 lb dog gets about 4 mL and a 20 lb dog about 8 mL.

Is children’s Benadryl safe for dogs?

The diphenhydramine is. The risk is in the other ingredients: avoid products with xylitol, and avoid "plus" or decongestant formulas. Some liquids also contain alcohol, which is best avoided for small dogs.

Sources

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